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Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Chromatin. --- Semen -- chemistry. --- Spermatozoa -- chemistry. --- Sperm-Ovum Interactions. --- Spermatogenesis --- Infertility, Male --- Sex chromatin --- Germ Cells --- Chromosome Structures --- Infertility --- Medicine --- Genetic Processes --- DNA Packaging --- Biological Science Disciplines --- Gene Expression Regulation --- Nucleoproteins --- Genitalia --- Genetic Structures --- Cells --- Proteins --- Genetic Phenomena --- Health Occupations --- Natural Science Disciplines --- Cell Physiological Processes --- Genital Diseases, Male --- Chromosomes --- Anatomy --- Male Urogenital Diseases --- Amino Acids, Peptides, and Proteins --- Intranuclear Space --- Urogenital System --- Phenomena and Processes --- Cell Physiological Phenomena --- Disciplines and Occupations --- Diseases --- Cell Nucleus Structures --- Chemicals and Drugs --- Cell Nucleus --- Intracellular Space --- Cellular Structures --- Spermatozoa --- Physiology --- Chromatin --- Chromatin Assembly and Disassembly --- Pathology --- DNA Damage --- Zoology --- Health & Biological Sciences --- Gynecology & Obstetrics --- Animal Anatomy & Embryology --- Genetic aspects --- Infertility, Male. --- Human reproductive technology. --- Spermatozoa. --- Male gametes --- Sperm --- Assisted human reproduction --- Assisted conception --- Conception --- Human assisted reproduction --- Human reproduction --- Male infertility --- Male sterility --- Sterility, Male --- Technological innovations --- Medicine. --- Obstetrics. --- Endocrinology. --- Reproductive medicine. --- Urology. --- Cell biology. --- Developmental biology. --- Medicine & Public Health. --- Reproductive Medicine. --- Developmental Biology. --- Cell Biology. --- Obstetrics/Perinatology. --- Gametes --- Semen --- Medical technology --- Reproductive technology --- Generative organs, Male --- Cytology. --- Obstetrics/Perinatology/Midwifery. --- Genitourinary organs --- Maternal-fetal medicine --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Development (Biology) --- Growth --- Ontogeny --- Internal medicine --- Hormones --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Health aspects --- Endocrinology .

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A growing majority of women in the western hemisphere have been delaying initiation of childbearing to later in life. Consequently, more women in their late 30s to early 40s are attempting to get pregnant for the first time than ever before. Since the incidence of most cancers increases with age, delayed childbearing results in more female cancer survivors interested in fertility preservation. In this book, the editors provide strategies for fertility preservation in women and men who require gonadotoxic treatment. In addition, epidemiologic, ethical, medico-legal, psychologic, and social aspects of fertility preservation are discussed. Using a format that combines concise scientific background with practical methodological information and easy-to-grasp algorithms, the chapters all conform to a uniform structure, including a brief abstract, keyword glossary, step by step protocol of laboratory procedures, key issues in commentary and a list of references. The result is a unique, practical reference guide for reproductive endocrinologists, urologists, embryologists, reproductive scientists, and oncologists.

Infertility -- Diagnosis. --- Infertility -- Hormone therapy. --- Reproductive Techniques, Assisted. --- Infertility --- Reproductive health --- Human reproduction --- Persons --- Named Groups --- Men --- Women --- Medicine --- Health & Biological Sciences --- Urology & Nephrology --- Clinical Endocrinology --- Gynecology & Obstetrics --- Prevention --- Fertility, Human. --- Cancer --- Endocrine aspects. --- Cancer endocrinology --- Hormonal aspects of cancer --- Human fertility --- Natality --- Hormonal aspects --- Medicine. --- Obstetrics. --- Endocrinology. --- Urology. --- Cell biology. --- Developmental biology. --- Medicine & Public Health. --- Developmental Biology. --- Cell Biology. --- Obstetrics/Perinatology. --- Demography --- Cytology. --- Obstetrics/Perinatology/Midwifery. --- Maternal-fetal medicine --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Development (Biology) --- Growth --- Ontogeny --- Genitourinary organs --- Internal medicine --- Hormones --- Diseases --- Endocrinology .

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This comprehensive, multidisciplinary guide provides an up-to-date presentation of fertility preservation techniques with male cancer patients and other challenging conditions. Divided into four thematic sections, part one provides an overview of the pathophysiologic processes interrelating cancer and its treatment with infertility and discusses different methods of sperm preservation and fertility outcomes in cancer patients. Part two then explores male fertility preservation in various non-cancerous conditions, such as immunosuppressed, hypogonadal and transgender patients. The fundamental principles of cryobiology and sperm optimization are covered in part three, which also offers essential building blocks for scientists to develop a sperm banking service and implement high standards of practice. The final section describes the current practices of male fertility preservation along with its psychological impact on patients, and extends beyond to future innovative methods—tissue preservation, xenografting and artificial gametes—being researched and implemented in this field. Fertility preservation among cancer patients and survivors is an evolving practice, which involves focused research and timely collaboration of professionals from related fields. The Complete Guide to Male Fertility Preservation is unique and original in its design and will appeal to a larger audience of andrologists, reproductive endocrinologists, urologists, embryologists, and all other clinicians practicing reproductive medicine and oncology.

Medicine. --- Oncology. --- Reproductive medicine. --- Andrology. --- Medicine & Public Health. --- Reproductive Medicine. --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Clinical sciences --- Medical profession --- Health aspects --- Fertility, Human. --- Male reproductive health. --- Men's reproductive health --- Human fertility --- Natality --- Men --- Reproductive health --- Demography --- Infertility --- Health and hygiene --- Oncology  . --- Tumors --- Generative organs, Male --- Health --- Endocrine aspects --- Diseases --- Physiology

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Andrology. --- Generative organs, Male --- Human reproduction --- Men --- Endocrine aspects --- Diseases --- Physiology

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General embryology. Developmental biology --- Histology. Cytology --- Pathological endocrinology --- Urology. Andrology --- Gynaecology. Obstetrics --- endocrinologie --- obstetrie --- urologie --- perinatale sterfte --- cytologie --- embryologie (geneeskunde) --- vroedkunde --- histologie